Thursday, October 1, 2009

Breaking Report: Huntingtin Aggregation Screen

On my desk today? Doumanis et al. (2009) RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation. PLoS One. 4(9)37275. Free on-line access. Authors report a primary screen in BG2 cells stably expressing a poly-Q EGFP thatform aggregates with a library they generated (about 7200 genes). Follow-up includes in vivo RNAi in fly eye and brain.

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