Kanoh H, Kuraishi T, Tong LL, Watanabe R, Nagata S, Kurata S. Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract. Biochem Biophys Res Commun. 2015 Sep 28. pii: S0006-291X(15)30654-9. PMID: 26427875.
From the abstract: "... In Drosophila, the Toll pathway confers damage
responses during bacterial infection and improper cell-fate control.
However, the intrinsic ligands and signaling mechanisms that potentiate
innate immune responses remain unknown. Here, we demonstrate that a
Drosophila larva-derived tissue extract strongly elicits Toll pathway
activation via the Toll receptor. Using this extract, we performed ex
vivo genome-wide RNAi screening in Drosophila cultured cells, and
identified several signaling factors that are required for host defense
and antimicrobial-peptide expression in Drosophila adults. ..."
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